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Development of superfine pulverizer and its application in pharmaceutical industry



With the continuous upgrading of comminution technology, the advent of ultra-fine pulverizer has become a new favorite in the field of traditional Chinese medicine comminution because it can save raw materials to a great extent. Because of its extremely high crushing fineness, it can reach the level of cell wall breaking, and the cell wall breaking rate of general medicinal materials is up to 95%. Therefore, it is widely used in drug research and clinical application. Superfine pulverizer has just been developed and used in the industrial scope, but with the continuous updating of technology, it has now adapted to many industries, such as medicine, pharmacy, biology, food, fine chemicals, plastics, ceramics and so on. Many pharmaceutical enterprises have achieved large-scale production capacity and filled in the blank of domestic field.

The bioavailability of traditional Chinese medicine can be improved after superfine grinding. The particle size of traditional Chinese medicine is more fine and uniform, the specific surface area is increased, the porosity is increased, the drug can be well dispersed, dissolved in gastrointestinal fluid, and the contact area with gastrointestinal dry membrane is increased, so it is easier to be absorbed by gastrointestinal tract, whether it is external patch or oral capsule.


For mineral medicinal materials, a part of them are water-insoluble substances. After ultra-fine treatment, due to the greatly reduced particle size, the dissolution and absorption rate in vivo can be increased and the absorption amount can be increased. In addition, raw materials can be saved to a great extent after superfine grinding of traditional Chinese medicine. A small dose can be used to obtain the curative effect of the original prescription. After superfine grinding, ordinary drugs can not be treated by extraction and decoction, so as to reduce the loss of effective components in the production process and maximize the use of raw materials.


Therefore, this technology is especially suitable for the comminution of ten precious and rare traditional Chinese medicines. Due to the increase of fineness, it can improve the sense of the day and is easy to take. On the other hand, because the ultra-fine pulverization is carried out in a fully closed dust-free system, the external pollution can be effectively avoided, and the microbial content and dust of the product can be controlled.


It can be seen that the ultra-fine pulverizer plays an extremely important role in important fields. Of course, there are still some deficiencies in this model, which requires the relevant enterprises to continuously improve the technology to improve the deficiencies, so that the production of ultra-fine pulverizer of traditional Chinese medicine can reach the production capacity of large-scale.


The appearance of superfine pulverizer has greatly improved the technical level of pharmaceutical machinery industry. However, it is far from enough to rely on some new equipment for the development of the industry. Other pharmaceutical equipment should learn from the pulverizer industry, constantly strengthen technological innovation and enhance the overall competitiveness of the pharmaceutical machinery industry. It is an ideal equipment for pharmaceutical manufacturers to pass GMP certification.


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